Alloferon and Zanamivir Show Effective Antiviral Activity against Influenza A Virus (H1N1) Infection In Vitro and In VivoArticle Published on 2022-12-302023-06-24 Journal: International Journal of Molecular Sciences [Category] 신종인플루엔자, [키워드] alloferon influenza virus A/H1N1 Lung inflammation zanamivir. [DOI] 10.3390/ijms24010678 PMC 바로가기
Jacareubin inhibits TLR4-induced lung inflammatory response caused by the RBD domain of SARS-CoV-2 Spike proteinArticle Published on 2022-12-012023-07-10 Journal: Pharmacological Reports [Category] COVID19(2023년), [키워드] coronavirus Lung inflammation RBD Spike protein TLR4. [DOI] 10.1007/s43440-022-00398-5 PMC 바로가기
Efficacy of ensitrelvir against SARS-CoV-2 in a delayed-treatment mouse modelArticle Published on 2022-10-282022-11-15 Journal: Journal of Antimicrobial Chemotherapy [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] acute respiratory syndrome Administered age anti-SARS-CoV-2 Antiviral Antiviral compound antiviral efficacy body weight Body weight loss caused Cell clinical development coronavirus coronavirus disease correlated COVID-19 demonstrated development dose dose-dependent manner effective Efficacy evaluated expression general treatment Health in vivo increased survival Inflammatory Intervention lung Lung inflammation Lung pathology mice mouse-adapted SARS-CoV-2 nucleocapsid protein pandemic patients with COVID-19 Post-infection protease pulmonary lesion quantified reduced reduced viral load RNA RT-qPCR Safe SARS-CoV-2 SARS-COV-2 infection Support suppressed survival target the SARS-CoV-2 titre treat Treatment Viral RNA was used were infected [DOI] 10.1093/jac/dkac257 PMC 바로가기
Efficacy of COVID-HIGIV in animal models of SARS-CoV-2 infectionArticle Published on 2022-10-102022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acute respiratory syndrome animal model anti-SARS-CoV-2 baseline Body weight loss caused China controls convalescent plasma coronavirus COVID-19 COVID-19 vaccines deaths Efficacy evaluated faster hamster hamsters Hospitalization Human Immunoglobulin intravenous Lung inflammation Lung pathology Lungs mice monoclonal antibody mouse model ongoing trial PBS plasma reduced SARS-CoV-2 SARS-COV-2 infection significantly Spread Support therapeutic option treated Treatment Viral load virus was reduced worldwide pandemic [DOI] 10.1038/s41598-022-21223-2 PMC 바로가기
Diet-Induced Obesity and NASH Impair Disease Recovery in SARS-CoV-2-Infected Golden HamstersArticle Published on 2022-09-172022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] angiotensin-converting enzyme 2 Blood controls coronavirus disease Coronavirus disease 2019 COVID-19 days post-infection disease early stage Efficacy exhibited favor fibrosis form hamster hamsters hepatocyte ballooning impair induce infected with SARS-CoV-2 Infection Inflammation Inflammatory cytokines less liver Liver fibrosis liver steatosis long-lasting Lung inflammation lung viral load mechanism NASH non-alcoholic steatohepatitis obese obese patient obesity obesity. pathophysiologic Patient pulmonary fibrosis relative replicate SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected hamsters Serum level severity of COVID-19 steatohepatitis sustained systemic inflammation the SARS-CoV-2 Treatment weight loss [DOI] 10.3390/v14092067 PMC 바로가기
Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19Article Published on 2022-09-012022-11-15 Journal: American journal of physiology. Lung cellular and [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE-2 ACE2 addition airway alveolar angiotensin-converting enzyme 2 anti-inflammatory effect Anti-inflammatory effects anti-inflammatory property antioxidant Antiviral Antiviral effect antiviral effects binding cell entry cleavage cleave Concentration COVID-19 cysteamine decrease determine disrupt drug drugs Effect effective functional hamster hemorrhage in vivo infected with SARS-CoV-2 Inflammation inhibit Injury intraperitoneally limit lung Lung inflammation Lung injury mechanism neutrophilic oxidative stress pseudovirus redox status reporter SARS-2-S SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike glycoprotein SARS-CoV-2 viruses significantly tested thiol drugs. thiol group viral infection virus infection [DOI] 10.1152/ajplung.00136.2022 PMC 바로가기
Dual effects of supplemental oxygen on pulmonary infection, inflammatory lung injury, and neuromodulation in aging and COVID-19Review article Published on 2022-09-012022-10-05 Journal: Free radical biology & medicine [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] activating Activation acute lung injury acute respiratory distress syndrome (ARDS) age aging analysis Anti-inflammatory antioxidant ARDS attenuate Biomarkers Blood oxygen saturation Brain cause caused cellular cellular damage Central nervous system Cholinergic anti-inflammatory pathway chronic inflammation clinical Clinical outcome COVID-19 COVID-19 patient COVID-19 patients death decrease Defense distress dysregulated Effect function functions humans hyperinflammation IMPROVE increase in infected with SARS-CoV-2 infections Inflammation inflammatory lung injury Inflammatory response inhibiting Innate immunity likelihood lung lung cells Lung inflammation macrophages master regulator Mitochondria morbidity and mortality oxidative oxidative stress oxygen Oxygen therapy pathway positive correlation positively correlated Postmortem prolonged exposure Pulmonary infection reactive oxygen specy receiving receptor regulate regulated resulting ROS Safe Sepsis shown Signaling supplemental oxygen Supplemental oxygen therapy susceptibility syndrome Therapeutic approach Toxicity treat α7 nicotinic acetylcholine receptor α7nAChR [DOI] 10.1016/j.freeradbiomed.2022.08.004 [Article Type] Review article
Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion proteinRBD-뉴클레오캡시드 융합단백질을 이용한 관심대상 야생형 및 SARS-CoV-2 변이체에 대한 중화항체 비의존성 면역 촉진Article Published on 2022-08-172022-09-11 Journal: Nature Communications [Category] SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] ablated angiotensin antibody Antigen B cell B cells Blood CD4 CD8 chimeric circumvent Clinical outcome convertase COVID-19 convalescent donors COVID-19 vaccine COVID-19 vaccines Delta Depletion detectable effector T cell effector T cells elicit elicited experimental model experimental models fusion protein generate hamster IFN-γ Immune escape Immunity immunization IMPROVE inactivated indicated individual Infection infection with SARS-CoV-2 less lethality levels of antibody Lung inflammation mice NAbs Neutralizing Neutralizing antibodies neutralizing antibody nucleocapsid omicron promote promotion PROTECT Protein protocol protocols RBD RBD protein Receptor binding domain reduction robust SARS-CoV-2 SARS-CoV-2 isolates SARS-CoV-2 vaccine SARS-CoV-2 variant shown spike Spin T cell T cells transferred vaccination Vaccine variants variants of concern Viral Viral load virus wild type wild-type [DOI] 10.1038/s41467-022-32547-y PMC 바로가기 [Article Type] Article
Human genetic factors associated with pneumonia risk, a cue for COVID-19 susceptibility폐렴 위험과 관련된 인간 유전적 요인, COVID-19 감수성의 신호Meta-Analysis Published on 2022-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] Coronavirus, 변종, 유전자 메커니즘, [키워드] acquisition age airway epithelium Alter Analysis applied article association calculated case-control studies cause Community community acquired community acquired pneumonia contribute coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 susceptibility CYP1A1 driven by effect size Egger eligible evaluated expressed Factor funnel plot Genetic genetic etiology Genetic variant genetic variants healthy controls heterogeneity host genetics Human identify key factor likelihood Lung inflammation marker Maximum likelihood meta-analysed Meta-analysis Mortality nosocomial Nosocomial pneumonia Odds ratio Pathogenesis Patient performed Pneumonia pneumonia. Prevalence publication bias respiratory tract infection risk risk allele statistical significance subgroup analysis susceptibility Variability variant variants Viral pneumonia was performed were used [DOI] 10.1016/j.meegid.2022.105299 PMC 바로가기 [Article Type] Meta-Analysis
Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19Review article Published on 2022-08-012022-10-05 Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 임상, 치료제, [키워드] activated acute respiratory syndrome anti-inflammatory drug antiviral drugs autophagy Autophagy regulation caused coronavirus Coronavirus disease 2019 COVID-19 Cytokine storm early stage Evidence indicate Infection Infectious disease Inflammasome inhibiting inhibitor involved late stage Lung inflammation NLRP3 NLRP3 inflammasome protein 3 provide Regulation replication of SARS-CoV-2 SARS-CoV-2 Stage targeting the cytokine storm therapeutic potential therapy [DOI] 10.1016/j.clim.2022.109093 [Article Type] Review article